Toward the next generation of research into small area effects on health : a synthesis of multilevel investigations published since July 1998.

To map out area effects on health research, this study had the following aims: (1) to inventory multilevel investigations of area effects on self rated health, cardiovascular diseases and risk factors, and mortality among adults; (2) to describe and critically discuss methodological approaches employed and results observed; and (3) to formulate selected recommendations for advancing the study of area effects on health. Overall, 86 studies were inventoried. Although several innovative methodological approaches and analytical designs were found, small areas are most often operationalised using administrative and statistical spatial units. Most studies used indicators of area socioeconomic status derived from censuses, and few provided information on the validity and reliability of measures of exposures. A consistent finding was that a significant portion of the variation in health is associated with area context independently of individual characteristics. Area effects on health, although significant in most studies, often depend on the health outcome studied, the measure of area exposure used, and the spatial scale at which associations are examined

The Minimum Wiener Connector

The Wiener index of a graph is the sum of all pairwise shortest-path distances between its vertices. In this paper we study the novel problem of finding a minimum Wiener connector: given a connected graph $G=(V,E)$ and a set $Q\subseteq V$ of query vertices, find a subgraph of $G$ that connects all query vertices and has minimum Wiener index. We show that The Minimum Wiener Connector admits a polynomial-time (albeit impractical) exact algorithm for the special case where the number of query vertices is bounded. We show that in general the problem is NP-hard, and has no PTAS unless $\mathbf{P} = \mathbf{NP}$. Our main contribution is a constant-factor approximation algorithm running in time $\widetilde{O}(|Q||E|)$. A thorough experimentation on a large variety of real-world graphs confirms that our method returns smaller and denser solutions than other methods, and does so by adding to the query set $Q$ a small number of important vertices (i.e., vertices with high centrality).Comment: Published in Proceedings of the 2015 ACM SIGMOD International Conference on Management of Dat

Thermal noise influences fluid flow in thin films during spinodal dewetting

Experiments on dewetting thin polymer films confirm the theoretical prediction that thermal noise can strongly influence characteristic time-scales of fluid flow and cause coarsening of typical length scales. Comparing the experiments with deterministic simulations, we show that the Navier-Stokes equation has to be extended by a conserved bulk noise term to accomplish the observed spectrum of capillary waves. Due to thermal fluctuations the spectrum changes from an exponential to a power law decay for large wavevectors. Also the time evolution of the typical wavevector of unstable perturbations exhibits noise induced coarsening that is absent in deterministic hydrodynamic flow.Comment: 4 pages, 3 figure

Flow establishment in a generic scramjet combustor

The establishment of a quasi-steady flow in a generic scramjet combustor was studied for the case of a time varying inflow to the combustor. Such transient flow is characteristic of the reflected shock tunnel and expansion tube test facilities. Several numerical simulations of hypervelocity flow through a straight duct combustor with either a side wall step fuel injector or a centrally located strut injector are presented. Comparisons were made between impulsively started but otherwise constant flow conditions (typical of the expansion tube or tailored operations of the reflected shock tunnel) and the relaxing flow produced by the 'undertailored' operations of the reflected shock tunnel. Generally the inviscid flow features, such as the shock pattern and pressure distribution, were unaffected by the time varying inlet conditions and approached steady state in approx. the times indicated by experimental correlations. However, viscous features, such as heat transfer and skin friction, were altered by the relaxing inlet flow conditions

Fibrational induction meets effects

This paper provides several induction rules that can be used to prove properties of effectful data types. Our results are semantic in nature and build upon Hermida and Jacobs’ fibrational formulation of induction for polynomial data types and its extension to all inductive data types by Ghani, Johann, and Fumex. An effectful data type μ(TF) is built from a functor F that describes data, and a monad T that computes effects. Our main contribution is to derive induction rules that are generic over all functors F and monads T such that μ(TF) exists. Along the way, we also derive a principle of definition by structural recursion for effectful data types that is similarly generic. Our induction rule is also generic over the kinds of properties to be proved: like the work on which we build, we work in a general fibrational setting and so can accommodate very general notions of properties, rather than just those of particular syntactic forms. We give examples exploiting the generality of our results, and show how our results specialize to those in the literature, particularly those of Filinski and Støvring

Antibody localization in horse, rabbit, and goat antilymphocyte sera

The localization of antibodies was studied in rabbit, goat, and horse ALS raised by weekly immunization with canine or human spleen cells for 4 to 12 weeks. A combination of analytic techniques was used including column chromatography, electrophoresis, immunoelectrophoresis, determination of protein concentration, and measurement of antibody titers. In the rabbit and goat ALS, virtually all of the leukoagglutinins and lymphocytotoxins were in the easily separable IgG; accidentally induced thromboagglutinins were in the same location. In the rabbit hemagglutinins were found in both the IgG and IgM, whereas in the goat these were almost exclusively in the IgM. The antiwhite cell antibodies were most widely distributed in the horse. The cytotoxins were primarily in the IgG, but the leukoagglutinins were most heavily concentrated in the T-equine globulin which consists mostly of IgA. By differential ammonium sulfate precipitation of a horse antidoglymphocyte serum, fractions were prepared that were rich in IgG and IgA. Both were able to delay the rejection of canine renal homografts, the IgA-rich preparation to a somewhat greater degree. The findings in this study have been discussed in relation to the refining techniques that have been used for the production of globulin from heterologous ALS. © 1970

Anomalous Density-of-States Fluctuations in Two-Dimensional Clean Metals

It is shown that density-of-states fluctuations, which can be interpreted as the order-parameter susceptibility \chi_OP in a Fermi liquid, are anomalously strong as a result of the existence of Goldstone modes and associated strong fluctuations. In a 2-d system with a long-range Coulomb interaction, a suitably defined \chi_OP diverges as 1/T^2 as a function of temperature in the limit of small wavenumber and frequency. In contrast, standard statistics suggest \chi_OP = O(T), a discrepancy of three powers of T. The reasons behind this surprising prediction, as well as ways to observe it, are discussed.Comment: 4 pp, revised version contains a substantially expanded derivatio